SEPN

Healthcare

Septerna, Inc.

$25.21-1.24 (-4.67%)

Prev Close

$26.45

Open

$26.49

High

$27.02

Low

$24.96

Volume

201.9K

Market Cap

$1.33B

P/E

—

Div Yield

—

Over the past 12 months, insider activity at Septerna, Inc. (SEPN) has been exclusively selling, with 0 insider purchases totaling $0.00 and 4 insider sales totaling $4.25M. The most recent insider transaction was by Shaikhly Samira (officer: Chief People Officer), who sold $3.96M worth of shares on Mar 4, 2026. Septerna, Inc. operates in the Healthcare sector, within the Biotechnology industry, with a market cap of $1.33B.

Buys (12M)

$0.00

Sells (12M)

$4.25M

Net Activity

Net Seller

$4.25M

Active Insiders

last 12 mo

SEPN Price Chart

SEPN Insider Trading Activity

Date	Insider	Role	Type	Shares	Avg Price	Value	Shares After
Mar 4, 2026↗	Shaikhly Samira	officer: Chief People Officer	Sell	140,906	$28.10	$3.96M	67,156
Feb 20, 2026↗	Bhatt Elizabeth	officer: President and COO	Sell	4,000	$28.97	$115.9K	176,009
Feb 18, 2026↗	Bhatt Elizabeth	President and COO	Sell	4,000	$28.97	$115.9K	0
Nov 13, 2025↗	Long Daniel D.	SVP, Drug Discovery	Sell	3,501	$18.06	$63.2K	92,911
Mar 10, 2025↗	Ezekowitz Alan		Buy	13,319	$6.93	$92.3K	117,420
Mar 6, 2025↗	Ezekowitz Alan		Buy	86,681	$5.95	$515.9K	104,101
Feb 27, 2025↗	Finer Jeffrey	CEO and President	Buy	17,000	$5.70	$97.0K	771,907
Feb 27, 2025↗	Labrucherie Gil M	Chief Financial Officer	Buy	10,000	$5.69	$56.9K	40,000
Feb 26, 2025↗	Third Rock Ventures VI, L.P.		Buy	18,861	$6.00	$113.1K	4,211,660
Feb 24, 2025↗	Third Rock Ventures VI, L.P.		Buy	1,040,342	$5.93	$6.17M	4,192,800
Feb 21, 2025↗	Labrucherie Gil M	Chief Financial Officer	Buy	30,000	$5.74	$172.3K	30,000
Oct 30, 2024↗	RA CAPITAL MANAGEMENT, L.P.		Buy	4,170,000	$18.00	$75.06M	5,523,920
Oct 28, 2024↗	Third Rock Ventures V, L.P.		Buy	650,000	$18.00	$11.70M	6,215,590

SEPN Insider Buying Activity

The following table shows recent insider purchases of Septerna, Inc. (SEPN) stock reported via SEC Form 4 filings.

Date	Insider	Role	Type	Shares	Avg Price	Value	Shares After
Mar 10, 2025↗	Ezekowitz Alan		Buy	13,319	$6.93	$92.3K	117,420
Mar 6, 2025↗	Ezekowitz Alan		Buy	86,681	$5.95	$515.9K	104,101
Feb 27, 2025↗	Finer Jeffrey	CEO and President	Buy	17,000	$5.70	$97.0K	771,907
Feb 27, 2025↗	Labrucherie Gil M	Chief Financial Officer	Buy	10,000	$5.69	$56.9K	40,000
Feb 26, 2025↗	Third Rock Ventures VI, L.P.		Buy	18,861	$6.00	$113.1K	4,211,660
Feb 24, 2025↗	Third Rock Ventures VI, L.P.		Buy	1,040,342	$5.93	$6.17M	4,192,800
Feb 21, 2025↗	Labrucherie Gil M	Chief Financial Officer	Buy	30,000	$5.74	$172.3K	30,000
Oct 30, 2024↗	RA CAPITAL MANAGEMENT, L.P.		Buy	4,170,000	$18.00	$75.06M	5,523,920
Oct 28, 2024↗	Third Rock Ventures V, L.P.		Buy	650,000	$18.00	$11.70M	6,215,590

SEPN Insider Selling Activity

The following table shows recent insider sales of Septerna, Inc. (SEPN) stock reported via SEC Form 4 filings.

Date	Insider	Role	Type	Shares	Avg Price	Value	Shares After
Mar 4, 2026↗	Shaikhly Samira	officer: Chief People Officer	Sell	140,906	$28.10	$3.96M	67,156
Feb 20, 2026↗	Bhatt Elizabeth	officer: President and COO	Sell	4,000	$28.97	$115.9K	176,009
Feb 18, 2026↗	Bhatt Elizabeth	President and COO	Sell	4,000	$28.97	$115.9K	0
Nov 13, 2025↗	Long Daniel D.	SVP, Drug Discovery	Sell	3,501	$18.06	$63.2K	92,911